Architecture is the modification of the natural environment to allow humans to dwell it.  It starts from the very basic human necessity to find a rest from the limitlessness of nature. The spaces and objects we build are meant to resonate with our physical, sensorial and cognitive necessities. In this class we discuss ideas about how neuroscience can assist the design of such spaces and objects. We present innovative methods of research, compare different approaches, and explore the realm of design possibilities through creative assignments.  The class provides the unique opportunity to learn from experts in the field and at the same time apply what learned by doing. This is a class to ponder the true meaning of “why we build.” A class where students can exercise their critical thinking and creativity exploring new approaches to answer questions relative to architectural design. Students are challenged with the design of a psychophysical experiment to study the perceptibility of architectural proportion in the Kimbell Art Museum designed by Louis Kahn.